학술논문
The impact of demographic, clinical, genetic, and imaging variables on tau PET status
Document Type
article
Author
Ossenkoppele, Rik; Leuzy, Antoine; Cho, Hanna; Sudre, Carole H; Strandberg, Olof; Smith, Ruben; Palmqvist, Sebastian; Mattsson-Carlgren, Niklas; Olsson, Tomas; Jögi, Jonas; Stormrud, Erik; Ryu, Young Hoon; Choi, Jae Yong; Boxer, Adam L; Gorno-Tempini, Maria L; Miller, Bruce L; Soleimani-Meigooni, David; Iaccarino, Leonardo; La Joie, Renaud; Borroni, Edilio; Klein, Gregory; Pontecorvo, Michael J; Devous, Michael D; Villeneuve, Sylvia; Lyoo, Chul Hyoung; Rabinovici, Gil D; Hansson, Oskar
Source
European Journal of Nuclear Medicine and Molecular Imaging. 48(7)
Subject
Language
Abstract
PurposeA substantial proportion of amyloid-β (Aβ)+ patients with clinically diagnosed Alzheimer's disease (AD) dementia and mild cognitive impairment (MCI) are tau PET-negative, while some clinically diagnosed non-AD neurodegenerative disorder (non-AD) patients or cognitively unimpaired (CU) subjects are tau PET-positive. We investigated which demographic, clinical, genetic, and imaging variables contributed to tau PET status.MethodsWe included 2338 participants (430 Aβ+ AD dementia, 381 Aβ+ MCI, 370 non-AD, and 1157 CU) who underwent [18F]flortaucipir (n = 1944) or [18F]RO948 (n = 719) PET. Tau PET positivity was determined in the entorhinal cortex, temporal meta-ROI, and Braak V-VI regions using previously established cutoffs. We performed bivariate binary logistic regression models with tau PET status (positive/negative) as dependent variable and age, sex, APOEε4, Aβ status (only in CU and non-AD analyses), MMSE, global white matter hyperintensities (WMH), and AD-signature cortical thickness as predictors. Additionally, we performed multivariable binary logistic regression models to account for all other predictors in the same model.ResultsTau PET positivity in the temporal meta-ROI was 88.6% for AD dementia, 46.5% for MCI, 9.5% for non-AD, and 6.1% for CU. Among Aβ+ participants with AD dementia and MCI, lower age, MMSE score, and AD-signature cortical thickness showed the strongest associations with tau PET positivity. In non-AD and CU participants, presence of Aβ was the strongest predictor of a positive tau PET scan.ConclusionWe identified several demographic, clinical, and neurobiological factors that are important to explain the variance in tau PET retention observed across the AD pathological continuum, non-AD neurodegenerative disorders, and cognitively unimpaired persons.