학술논문
Systemic lupus erythematosus phenotypes formed from machine learning with a specific focus on cognitive impairment.
Document Type
article
Author
Barraclough, Michelle; Erdman, Lauren; Diaz-Martinez, Juan; Knight, Andrea; Bingham, Kathleen; Su, Jiandong; Kakvan, Mahta; Grajales, Carolina; Tartaglia, Maria; Ruttan, Lesley; Wither, Joan; Choi, May; Bonilla, Dennisse; Appenzeller, Simone; Parker, Ben; Goldenberg, Anna; Beaton, Dorcas; Green, Robin; Bruce, Ian; Touma, Zahi; Katz, Patricia
Source
Rheumatology. 62(11)
Subject
Language
Abstract
OBJECTIVE: To phenotype SLE based on symptom burden (disease damage, system involvement and patient reported outcomes), with a specific focus on objective and subjective cognitive function. METHODS: SLE patients ages 18-65 years underwent objective cognitive assessment using the ACR Neuropsychological Battery (ACR-NB) and data were collected on demographic and clinical variables, disease burden/activity, health-related quality of life (HRQoL), depression, anxiety, fatigue and perceived cognitive deficits. Similarity network fusion (SNF) was used to identify patient subtypes. Differences between the subtypes were evaluated using Kruskal-Wallis and χ2 tests. RESULTS: Of the 238 patients, 90% were female, with a mean age of 41 years (s.d. 12) and a disease duration of 14 years (s.d. 10) at the study visit. The SNF analysis defined two subtypes (A and B) with distinct patterns in objective and subjective cognitive function, disease burden/damage, HRQoL, anxiety and depression. Subtype A performed worst on all significantly different tests of objective cognitive function (P