학술논문

Saline versus gadolinium-enhanced magnetic resonance arthrography of porcine cartilage.
Document Type
article
Source
Academic radiology. 4(2)
Subject
Cartilage
Articular
Animals
Swine
Sodium Chloride
Gadolinium
Meglumine
Pentetic Acid
Gadolinium DTPA
Organometallic Compounds
Drug Combinations
Contrast Media
Observer Variation
Magnetic Resonance Imaging
Sensitivity and Specificity
arthrography
cartilage
MR
gadolinium
Cartilage
Articular
cartilage
MR
Nuclear Medicine & Medical Imaging
Clinical Sciences
Language
Abstract
Rationale and objectivesThe authors compared saline and dilute gadopentetate dimeglumine as injectants for magnetic resonance (MR) arthrography.MethodsSixty-three lesions were created on the joint surfaces of six pig patellas. MR arthrography (1.5 T) was performed with the specimens in saline and then in 2 mmol gadopentetate dimeglumine by using fat-saturated two-dimensional (2D) and three-dimensional (3D) sequences. Two musculoskeletal radiologists independently interpreted the images.ResultsAt 2D MR arthrography, reader 1 performed equally well with saline and gadolinium solutes, whereas reader 2 had better sensitivity with the saline solute (P < .05); interobserver agreement was equivalent for saline and gadolinium solutes. With 3D MR arthrography, reader 2 performed equally well with saline and gadolinium solutes, whereas reader 1 had better sensitivity (P < .0001) but poorer specificity (P < .001) with the gadolinium solute; interobserver agreement was significantly better for saline than for gadopentetate dimeglumine (P < .05).ConclusionIn this initial evaluation, there was no clear advantage to using gadolinium-enhanced MR arthrography over saline MR arthrography for detecting lesions in porcine hyaline cartilage.