학술논문
Evaluation of transplacental transfer of mRNA vaccine products and functional antibodies during pregnancy and infancy
Document Type
article
Author
Prahl, Mary; Golan, Yarden; Cassidy, Arianna G; Matsui, Yusuke; Li, Lin; Alvarenga, Bonny; Chen, Hao; Jigmeddagva, Unurzul; Lin, Christine Y; Gonzalez, Veronica J; Chidboy, Megan A; Warrier, Lakshmi; Buarpung, Sirirak; Murtha, Amy P; Flaherman, Valerie J; Greene, Warner C; Wu, Alan HB; Lynch, Kara L; Rajan, Jayant; Gaw, Stephanie L
Source
Nature Communications. 13(1)
Subject
Language
Abstract
Studies are needed to evaluate the safety and effectiveness of mRNA SARS-CoV-2 vaccination during pregnancy, and the levels of protection provided to their newborns through placental transfer of antibodies. Here, we evaluate the transplacental transfer of mRNA vaccine products and functional anti-SARS-CoV-2 antibodies during pregnancy and early infancy in a cohort of 20 individuals vaccinated during late pregnancy. We find no evidence of mRNA vaccine products in maternal blood, placenta tissue, or cord blood at delivery. However, we find time-dependent efficient transfer of IgG and neutralizing antibodies to the neonate that persists during early infancy. Additionally, using phage immunoprecipitation sequencing, we find a vaccine-specific signature of SARS-CoV-2 Spike protein epitope binding that is transplacentally transferred during pregnancy. Timing of vaccination during pregnancy is critical to ensure transplacental transfer of protective antibodies during early infancy.