학술논문
Differential Vulnerability of Hippocampal Subfields in Primary Age-Related Tauopathy and Chronic Traumatic Encephalopathy.
Document Type
article
Author
Farrell, Kurt; Iida, Megan A; Cherry, Jonathan D; Casella, Alicia; Stein, Thor D; Bieniek, Kevin F; Walker, Jamie M; Richardson, Timothy E; White, Charles L; Alvarez, Victor E; Huber, Bertrand R; Dickson, Dennis W; Insausti, Ricardo; Dams-O'Connor, Kristen; Vonsattel, Jean-Paul; Teich, Andy F; Gearing, Marla; Glass, Jonathan; Troncoso, Juan C; Frosch, Matthew P; Hyman, Bradley T; Murray, Melissa E; Attems, Johannes; Flanagan, Margaret E; Mao, Qinwen; Mesulam, M-Marsel; Weintraub, Sandra; Woltjer, Randy L; Pham, Thao; Kofler, Julia; Schneider, Julie A; Yu, Lei; Purohit, Dushyant P; Haroutunian, Vahram; Hof, Patrick R; Gandy, Sam; Sano, Mary; Beach, Thomas G; Poon, Wayne; Kawas, Claudia H; Corrada, María M; Rissman, Robert A; Metcalf, Jeff; Shuldberg, Sara; Salehi, Bahar; Nelson, Peter T; Trojanowski, John Q; Lee, Edward B; Wolk, David A; McMillan, Corey T; Keene, C Dirk; Latimer, Caitlin S; Montine, Thomas J; Kovacs, Gabor G; Lutz, Mirjam I; Fischer, Peter; Perrin, Richard J; Cairns, Nigel J; McKee, Ann C; Crary, John F
Source
Journal of Neuropathology & Experimental Neurology. 81(10)
Subject
Language
Abstract
Chronic traumatic encephalopathy (CTE) is a tauopathy associated with repetitive mild head impacts characterized by perivascular hyperphosphorylated tau (p-tau) in neurofibrillary tangles (NFTs) and neurites in the depths of the neocortical sulci. In moderate to advanced CTE, NFTs accumulate in the hippocampus, potentially overlapping neuroanatomically with primary age-related tauopathy (PART), an age-related tauopathy characterized by Alzheimer disease-like tau pathology in the hippocampus devoid of amyloid plaques. We measured p-tau burden using positive-pixel counts on immunohistochemically stained and neuroanatomically segmented hippocampal tissue. Subjects with CTE had a higher total p-tau burden than PART subjects in all sectors (p = 0.005). Within groups, PART had significantly higher total p-tau burden in CA1/subiculum compared to CA3 (p = 0.02) and CA4 (p = 0.01) and total p-tau burden in CA2 trended higher than CA4 (p = 0.06). In CTE, total p-tau burden in CA1/subiculum was significantly higher than in the dentate gyrus; and CA2 also trended higher than dentate gyrus (p = 0.01, p = 0.06). When controlling for p-tau burden across the entire hippocampus, CA3 and CA4 had significantly higher p-tau burden in CTE than PART (p