학술논문

Predictors of survival trajectories among women with epithelial ovarian cancer
Document Type
article
Source
Gynecologic Oncology. 156(2)
Subject
Biomedical and Clinical Sciences
Oncology and Carcinogenesis
Rare Diseases
Clinical Research
Ovarian Cancer
Prevention
Cancer
2.4 Surveillance and distribution
Aetiology
Good Health and Well Being
Aged
Black People
Carcinoma
Ovarian Epithelial
Female
Humans
Middle Aged
Native Hawaiian or Other Pacific Islander
Neoplasm Staging
Ovarian Neoplasms
Prognosis
SEER Program
United States
White People
Ovarian cancer
Long-term survivors
Mortality
Histotype
Paediatrics and Reproductive Medicine
Oncology & Carcinogenesis
Clinical sciences
Oncology and carcinogenesis
Reproductive medicine
Language
Abstract
ObjectiveAlthough ovarian cancer is a deadly disease, approximately a third of women survive ≥9 years after diagnosis. The factors associated with achieving long-term survival are not well understood. In this study, data from the Surveillance, Epidemiology, and End Results (SEER) program were used to determine predictors of survival trajectories among women with epithelial ovarian cancer and across histotype (high-grade serous carcinoma (HGSC) and non-HGSC).MethodsData on 35,868 women diagnosed with epithelial ovarian cancer in 2004-2016 were extracted from SEER. Extended Cox proportional hazards regression was used to estimate overall and histotype-specific associations between patient and tumor characteristics and all-cause mortality within each survival time (t) interval (t 70 years at diagnosis, where a high risk of mortality was observed in both the t