학술논문
GWAS of follicular lymphoma reveals allelic heterogeneity at 6p21.32 and suggests shared genetic susceptibility with diffuse large B-cell lymphoma.
Document Type
article
Author
Smedby, Karin; Foo, Jia; Skibola, Christine; Darabi, Hatef; Conde, Lucia; Hjalgrim, Henrik; Kumar, Vikrant; Chang, Ellen; Rothman, Nathaniel; Cerhan, James; Brooks-Wilson, Angela; Rehnberg, Emil; Irwan, Ishak; Ryder, Lars; Brown, Peter; Bracci, Paige; Agana, Luz; Riby, Jacques; Cozen, Wendy; Davis, Scott; Hartge, Patricia; Morton, Lindsay; Severson, Richard; Wang, Sophia; Slager, Susan; Fredericksen, Zachary; Novak, Anne; Kay, Neil; Habermann, Thomas; Armstrong, Bruce; Kricker, Anne; Milliken, Sam; Purdue, Mark; Vajdic, Claire; Boyle, Peter; Lan, Qing; Zahm, Shelia; Zhang, Yawei; Zheng, Tongzhang; Leach, Stephen; Spinelli, John; Smith, Martyn T.; Chanock, Stephen; Padyukov, Leonid; Alfredsson, Lars; Klareskog, Lars; Glimelius, Bengt; Melbye, Mads; Liu, Edison; Adami, Hans-Olov; Humphreys, Keith; Liu, Jianjun
Source
PLoS Genetics. 7(4)
Subject
Language
Abstract
Non-Hodgkin lymphoma (NHL) represents a diverse group of hematological malignancies, of which follicular lymphoma (FL) is a prevalent subtype. A previous genome-wide association study has established a marker, rs10484561 in the human leukocyte antigen (HLA) class II region on 6p21.32 associated with increased FL risk. Here, in a three-stage genome-wide association study, starting with a genome-wide scan of 379 FL cases and 791 controls followed by validation in 1,049 cases and 5,790 controls, we identified a second independent FL-associated locus on 6p21.32, rs2647012 (OR(combined) = 0.64, P(combined) = 2 × 10(-21)) located 962 bp away from rs10484561 (r(2)