학술논문
Impact of SARS-CoV-2 Infection on the Association Between Laboratory Tests and Severe Outcomes Among Hospitalized Children.
Document Type
article
Author
Xie, Jianling; Kuppermann, Nathan; Florin, Todd; Tancredi, Daniel; Funk, Anna; Kim, Kelly; Salvadori, Marina; Yock-Corrales, Adriana; Shah, Nipam; Breslin, Kristen; Chaudhari, Pradip; Bergmann, Kelly; Ahmad, Fahd; Nebhrajani, Jasmine; Mintegi, Santiago; Gangoiti, Iker; Plint, Amy; Avva, Usha; Gardiner, Michael; Malley, Richard; Finkelstein, Yaron; Dalziel, Stuart; Bhatt, Maala; Kannikeswaran, Nirupama; Caperell, Kerry; Campos, Carmen; Sabhaney, Vikram; Chong, Shu-Ling; Lunoe, Maren; Rogers, Alexander; Becker, Sarah; Borland, Meredith; Sartori, Laura; Pavlicich, Viviana; Rino, Pedro; Morrison, Andrea; Neuman, Mark; Poonai, Naveen; Simon, Norma-Jean; Kam, April; Kwok, Maria; Morris, Claudia; Palumbo, Laura; Ambroggio, Lilliam; Navanandan, Nidhya; Eckerle, Michelle; Klassen, Terry; Payne, Daniel; Cherry, Jonathan; Waseem, Muhammad; Dixon, Andrew; Ferre, Isabel; Freedman, Stephen
Source
Open Forum Infectious Diseases. 10(10)
Subject
Language
Abstract
BACKGROUND: To assist clinicians with identifying children at risk of severe outcomes, we assessed the association between laboratory findings and severe outcomes among severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected children and determined if SARS-CoV-2 test result status modified the associations. METHODS: We conducted a cross-sectional analysis of participants tested for SARS-CoV-2 infection in 41 pediatric emergency departments in 10 countries. Participants were hospitalized, had laboratory testing performed, and completed 14-day follow-up. The primary objective was to assess the associations between laboratory findings and severe outcomes. The secondary objective was to determine if the SARS-CoV-2 test result modified the associations. RESULTS: We included 1817 participants; 522 (28.7%) SARS-CoV-2 test-positive and 1295 (71.3%) test-negative. Seventy-five (14.4%) test-positive and 174 (13.4%) test-negative children experienced severe outcomes. In regression analysis, we found that among SARS-CoV-2-positive children, procalcitonin ≥0.5 ng/mL (adjusted odds ratio [aOR], 9.14; 95% CI, 2.90-28.80), ferritin >500 ng/mL (aOR, 7.95; 95% CI, 1.89-33.44), D-dimer ≥1500 ng/mL (aOR, 4.57; 95% CI, 1.12-18.68), serum glucose ≥120 mg/dL (aOR, 2.01; 95% CI, 1.06-3.81), lymphocyte count