학술논문

Interstitial lung disease diagnosis and prognosis using an AI system integrating longitudinal data
Document Type
article
Source
Nature Communications. 14(1)
Subject
Biomedical and Clinical Sciences
Clinical Sciences
Rare Diseases
Biomedical Imaging
Clinical Research
Lung
7.3 Management and decision making
4.1 Discovery and preclinical testing of markers and technologies
Management of diseases and conditions
4.2 Evaluation of markers and technologies
Detection
screening and diagnosis
Respiratory
Humans
Lung Diseases
Interstitial
Disease Progression
Thorax
Tomography
X-Ray Computed
Retrospective Studies
Language
Abstract
For accurate diagnosis of interstitial lung disease (ILD), a consensus of radiologic, pathological, and clinical findings is vital. Management of ILD also requires thorough follow-up with computed tomography (CT) studies and lung function tests to assess disease progression, severity, and response to treatment. However, accurate classification of ILD subtypes can be challenging, especially for those not accustomed to reading chest CTs regularly. Dynamic models to predict patient survival rates based on longitudinal data are challenging to create due to disease complexity, variation, and irregular visit intervals. Here, we utilize RadImageNet pretrained models to diagnose five types of ILD with multimodal data and a transformer model to determine a patient's 3-year survival rate. When clinical history and associated CT scans are available, the proposed deep learning system can help clinicians diagnose and classify ILD patients and, importantly, dynamically predict disease progression and prognosis.