학술논문
Wait Time Advantage for Transplant Candidates With HIV Who Accept Kidneys From Donors With HIV Under the HOPE Act.
Document Type
article
Author
Motter, Jennifer; Hussain, Sarah; Brown, Diane; Florman, Sander; Rana, Meenakshi; Friedman-Moraco, Rachel; Gilbert, Alexander; Stock, Peter; Mehta, Shikha; Mehta, Sapna; Stosor, Valentina; Elias, Nahel; Pereira, Marcus; Haidar, Ghady; Malinis, Maricar; Morris, Michele; Hand, Jonathan; Aslam, Saima; Schaenman, Joanna; Baddley, John; Small, Catherine; Wojciechowski, David; Santos, Carlos; Blumberg, Emily; Odim, Jonah; Apewokin, Senu; Giorgakis, Emmanouil; Bowring, Mary; Werbel, William; Desai, Niraj; Tobian, Aaron; Segev, Dorry; Massie, Allan; Durand, Christine
Source
Transplantation. 108(3)
Subject
Language
Abstract
BACKGROUND: Kidney transplant (KT) candidates with HIV face higher mortality on the waitlist compared with candidates without HIV. Because the HIV Organ Policy Equity (HOPE) Act has expanded the donor pool to allow donors with HIV (D + ), it is crucial to understand whether this has impacted transplant rates for this population. METHODS: Using a linkage between the HOPE in Action trial (NCT03500315) and Scientific Registry of Transplant Recipients, we identified 324 candidates listed for D + kidneys (HOPE) compared with 46 025 candidates not listed for D + kidneys (non-HOPE) at the same centers between April 26, 2018, and May 24, 2022. We characterized KT rate, KT type (D + , false-positive [FP; donor with false-positive HIV testing], D - [donor without HIV], living donor [LD]) and quantified the association between HOPE enrollment and KT rate using multivariable Cox regression with center-level clustering; HOPE was a time-varying exposure. RESULTS: HOPE candidates were more likely male individuals (79% versus 62%), Black (73% versus 35%), and publicly insured (71% versus 52%; P