학술논문

New Horizons in Hyperpolarized 13C MRI
Document Type
article
Source
Molecular Imaging and Biology. 26(2)
Subject
Biomedical and Clinical Sciences
Clinical Sciences
Biomedical Imaging
Detection
screening and diagnosis
4.1 Discovery and preclinical testing of markers and technologies
Humans
Magnetic Resonance Imaging
Magnetic Resonance Spectroscopy
Medical Oncology
Consensus
Hyperpolarized 13C
Metabolism
Metabolic imaging
MR spectroscopy
MRI
Physiology
Nuclear Medicine & Medical Imaging
Clinical sciences
Language
Abstract
Hyperpolarization techniques significantly enhance the sensitivity of magnetic resonance (MR) and thus present fascinating new directions for research and applications with in vivo MR imaging and spectroscopy (MRI/S). Hyperpolarized 13C MRI/S, in particular, enables real-time non-invasive assessment of metabolic processes and holds great promise for a diverse range of clinical applications spanning fields like oncology, neurology, and cardiology, with a potential for improving early diagnosis of disease, patient stratification, and therapy response assessment. Despite its potential, technical challenges remain for achieving clinical translation. This paper provides an overview of the discussions that took place at the international workshop "New Horizons in Hyperpolarized 13C MRI," in March 2023 at the Bavarian Academy of Sciences and Humanities, Munich, Germany. The workshop covered new developments, as well as future directions, in topics including polarization techniques (particularly focusing on parahydrogen-based methods), novel probes, considerations related to data acquisition and analysis, and emerging clinical applications in oncology and other fields.