학술논문
Gene expression associations with body mass index in the Multi-Ethnic Study of Atherosclerosis
Document Type
article
Author
Vargas, Luciana B; Lange, Leslie A; Ferrier, Kendra; Aguet, François; Ardlie, Kristin; Gabriel, Stacey; Gupta, Namrata; Smith, Joshua D; Blackwell, Thomas W; Ding, Jingzhong; Durda, Peter; Tracy, Russell P; Liu, Yongmei; Taylor, Kent D; Craig Johnson, W; Rich, Stephen S; Rotter, Jerome I; Lange, Ethan M; Konigsberg, Iain R
Source
International Journal of Obesity. 47(2)
Subject
Language
Abstract
Background/objectivesObesity, defined as excessive fat accumulation that represents a health risk, is increasing in adults and children, reaching global epidemic proportions. Body mass index (BMI) correlates with body fat and future health risk, yet differs in prediction by fat distribution, across populations and by age. Nonetheless, few genetic studies of BMI have been conducted in ancestrally diverse populations. Gene expression association with BMI was assessed in the Multi-Ethnic Study of Atherosclerosis (MESA) in four self-identified race and ethnicity (SIRE) groups to identify genes associated with obesity.Subjects/methodsRNA-sequencing was performed on 1096 MESA participants (37.8% white, 24.3% Hispanic, 28.4% African American, and 9.5% Chinese American) and linear models were used to assess the association of expression from each gene for its effect on BMI, adjusting for age, sex, sequencing center, study site, five expression and four genetic principal components in each self-identified race group. Sample-size-weighted meta-analysis was performed to identify genes with BMI-associated expression across ancestry groups.ResultsWithin individual SIRE groups, there were zero to three genes whose expression is significantly (p