학술논문
Examining Sex-Differentiated Genetic Effects Across Neuropsychiatric and Behavioral Traits.
Document Type
article
Author
Martin, Joanna; Khramtsova, Ekaterina A; Goleva, Slavina B; Blokland, Gabriëlla AM; Traglia, Michela; Walters, Raymond K; Hübel, Christopher; Coleman, Jonathan RI; Breen, Gerome; Børglum, Anders D; Demontis, Ditte; Grove, Jakob; Werge, Thomas; Bralten, Janita; Bulik, Cynthia M; Lee, Phil H; Mathews, Carol A; Peterson, Roseann E; Winham, Stacey J; Wray, Naomi; Edenberg, Howard J; Guo, Wei; Yao, Yin; Neale, Benjamin M; Faraone, Stephen V; Petryshen, Tracey L; Weiss, Lauren A; Duncan, Laramie E; Goldstein, Jill M; Smoller, Jordan W; Stranger, Barbara E; Davis, Lea K; Sex Differences Cross-Disorder Analysis Group of the Psychiatric Genomics Consortium
Source
Biological psychiatry. 89(12)
Subject
Language
Abstract
BackgroundThe origin of sex differences in prevalence and presentation of neuropsychiatric and behavioral traits is largely unknown. Given established genetic contributions and correlations, we tested for a sex-differentiated genetic architecture within and between traits.MethodsUsing European ancestry genome-wide association summary statistics for 20 neuropsychiatric and behavioral traits, we tested for sex differences in single nucleotide polymorphism (SNP)-based heritability and genetic correlation (rg < 1). For each trait, we computed per-SNP z scores from sex-stratified regression coefficients and identified genes with sex-differentiated effects using a gene-based approach. We calculated correlation coefficients between z scores to test for shared sex-differentiated effects. Finally, we tested for sex differences in across-trait genetic correlations.ResultsWe observed no consistent sex differences in SNP-based heritability. Between-sex, within-trait genetic correlations were high, although