학술논문
Low and High Birth Weights Are Risk Factors for Nonalcoholic Fatty Liver Disease in Children
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article
Author
Newton, Kimberly P; Feldman, Haruna S; Chambers, Christina D; Wilson, Laura; Behling, Cynthia; Clark, Jeanne M; Molleston, Jean P; Chalasani, Naga; Sanyal, Arun J; Fishbein, Mark H; Lavine, Joel E; Schwimmer, Jeffrey B; Network, Nonalcoholic Steatohepatitis Clinical Research; Abrams, Stephanie H; Barlow, Sarah; Himes, Ryan; Krisnamurthy, Rajesh; Maldonado, Leanel; Mahabir, Rory; Carr, April; Bernstein, Kimberlee; Bramlage, Kristin; Cecil, Kim; DeVore, Stephanie; Kohli, Rohit; Lake, Kathleen; Podberesky, Daniel; Towbin, Alex; Xanthakos, Stavra; Allende, Daniela; Dasarathy, Srinivasan; McCullough, Arthur J; Pagadala, Mangesh; Pai, Rish; Winston, Cha'Ron; Behr, Gerald; Lefkowitch, Jay H; Mencin, Ali; Reynoso, Elena; Abdelmalek, Manal F; Bashir, Mustafa; Buie, Stephanie; Diehl, Anna Mae; Guy, Cynthia; Kigongo, Christopher; Malik, David; Pan, Yi-Ping; Piercy, Dawn; Kopping, Mariko; Thrasher, Tyler; Alazraki, Adina; Cleeton, Rebecca; Cordero, Maria; Hernandez, Albert; Karpen, Saul; Munos, Jessica Cruz; Raviele, Nicholas; Vos, Miriam; Bozic, Molly; Cummings, Oscar W; Gawrieh, Samer; Klipsch, Ann; Ragozzino, Emily; Ragozzino, Linda; Sandrasegaran, Kumar; Subbarao, Girish; Vuppalanchi, Raj; Walker, Laura; Kafka, Kimberly; Scheimann, Ann; Ito, Joy; Mohammad, Saeed; Rigsby, Cynthia; Sharda, Lisa; Whitington, Peter F; Cattoor, Theresa; Derdoy, Jose; Freebersyser, Janet; Jain, Ajay; King, Debra; Lai, Jinping; Osmack, Pat; Siegner, Joan; Stewart, Susan; Neuschwander-Tetri, Brent A; Torretta, Susan; Wriston, Kristina; Assadian, Fereshteh; Barone, Vanessa; Gonzalez, Maria Cardona; Davila, Jodie; Fix, Oren; Hennessey, Kelly Anne; Kowdley, Kris V; Lopez, Kacie
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Abstract
ObjectivesTo examine the distribution of birth weight in children with nonalcoholic fatty liver disease (NAFLD) compared with the general US population, and to investigate the relationship between birth weight and severity of NAFLD.Study designA multicenter, cross-sectional study of children with biopsy-proven NAFLD enrolled in the Nonalcoholic Steatohepatitis Clinical Research Network Database. Birth weight was categorized as low birth weight (LBW), normal birth weight (NBW), or high birth weight (HBW) and compared with the birth weight distribution in the general US population. The severity of liver histology was assessed by birth weight category.ResultsChildren with NAFLD (n = 538) had overrepresentation of both LBW and HBW compared with the general US population (LBW, 9.3%; NBW, 75.8%; HBW, 14.9% vs LBW, 6.1%; NBW, 83.5%; HBW 10.5%; P