학술논문
Virology under the Microscope-a Call for Rational Discourse.
Document Type
article
Author
Goodrum, Felicia; Lowen, Anice C; Lakdawala, Seema; Alwine, James; Casadevall, Arturo; Imperiale, Michael J; Atwood, Walter; Avgousti, Daphne; Baines, Joel; Banfield, Bruce; Banks, Lawrence; Bhaduri-McIntosh, Sumita; Bhattacharya, Deepta; Blanco-Melo, Daniel; Bloom, David; Boon, Adrianus; Boulant, Steeve; Brandt, Curtis; Broadbent, Andrew; Brooke, Christopher; Cameron, Craig; Campos, Samuel; Caposio, Patrizia; Chan, Gary; Cliffe, Anna; Coffin, John; Collins, Kathleen; Damania, Blossom; Daugherty, Matthew; Debbink, Kari; DeCaprio, James; Dermody, Terence; Dikeakos, Jimmy; DiMaio, Daniel; Dinglasan, Rhoel; Duprex, W Paul; Dutch, Rebecca; Elde, Nels; Emerman, Michael; Enquist, Lynn; Fane, Bentley; Fernandez-Sesma, Ana; Flenniken, Michelle; Frappier, Lori; Frieman, Matthew; Frueh, Klaus; Gack, Michaela; Gaglia, Marta; Gallagher, Tom; Galloway, Denise; García-Sastre, Adolfo; Geballe, Adam; Glaunsinger, Britt; Goff, Stephen; Greninger, Alexander; Hancock, Meaghan; Harris, Eva; Heaton, Nicholas; Heise, Mark; Heldwein, Ekaterina; Hogue, Brenda; Horner, Stacy; Hutchinson, Edward; Hyser, Joseph; Jackson, William; Kalejta, Robert; Kamil, Jeremy; Karst, Stephanie; Kirchhoff, Frank; Knipe, David; Kowalik, Timothy; Lagunoff, Michael; Laimins, Laimonis; Langlois, Ryan; Lauring, Adam; Lee, Benhur; Leib, David; Liu, Shan-Lu; Longnecker, Richard; Lopez, Carolina; Luftig, Micah; Lund, Jennifer; Manicassamy, Balaji; McFadden, Grant; McIntosh, Michael; Mehle, Andrew; Miller, W Allen; Mohr, Ian; Moody, Cary; Moorman, Nathaniel; Moscona, Anne; Mounce, Bryan; Munger, Joshua; Münger, Karl; Murphy, Eain; Naghavi, Mojgan; Nelson, Jay; Neufeldt, Christopher; Nikolich, Janko; O'Connor, Christine
Source
mSphere. 8(2)
Subject
Language
Abstract
Viruses have brought humanity many challenges: respiratory infection, cancer, neurological impairment and immunosuppression to name a few. Virology research over the last 60+ years has responded to reduce this disease burden with vaccines and antivirals. Despite this long history, the COVID-19 pandemic has brought unprecedented attention to the field of virology. Some of this attention is focused on concern about the safe conduct of research with human pathogens. A small but vocal group of individuals has seized upon these concerns - conflating legitimate questions about safely conducting virus-related research with uncertainties over the origins of SARS-CoV-2. The result has fueled public confusion and, in many instances, ill-informed condemnation of virology. With this article, we seek to promote a return to rational discourse. We explain the use of gain-of-function approaches in science, discuss the possible origins of SARS-CoV-2 and outline current regulatory structures that provide oversight for virological research in the United States. By offering our expertise, we - a broad group of working virologists - seek to aid policy makers in navigating these controversial issues. Balanced, evidence-based discourse is essential to addressing public concern while maintaining and expanding much-needed research in virology.