학술논문
Flortaucipir tau PET findings from former professional and college American football players in the DIAGNOSE CTE research project.
Document Type
article
Author
Su, Yi; Protas, Hillary; Luo, Ji; Chen, Kewei; Alosco, Michael; Adler, Charles; Balcer, Laura; Bernick, Charles; Au, Rhoda; Banks, Sarah; Barr, William; Coleman, Michael; Dodick, David; Katz, Douglas; Marek, Kenneth; McClean, Michael; McKee, Ann; Mez, Jesse; Daneshvar, Daniel; Palmisano, Joseph; Peskind, Elaine; Turner, Robert; Wethe, Jennifer; Johnson, Keith; Tripodis, Yorghos; Cummings, Jeffrey; Shenton, Martha; Stern, Robert; Reiman, Eric; Rabinovici, Gil
Source
Alzheimers & Dementia: The Journal of the Alzheimers Association. 20(3)
Subject
Language
Abstract
INTRODUCTION: Tau is a key pathology in chronic traumatic encephalopathy (CTE). Here, we report our findings in tau positron emission tomography (PET) measurements from the DIAGNOSE CTE Research Project. METHOD: We compare flortaucipir PET measures from 104 former professional players (PRO), 58 former college football players (COL), and 56 same-age men without exposure to repetitive head impacts (RHI) or traumatic brain injury (unexposed [UE]); characterize their associations with RHI exposure; and compare players who did or did not meet diagnostic criteria for traumatic encephalopathy syndrome (TES). RESULTS: Significantly elevated flortaucipir uptake was observed in former football players (PRO+COL) in prespecified regions (p