학술논문
Consuming Sucrose- or HFCS-Sweetened Beverages Increases Hepatic Lipid and Decreases Insulin Sensitivity in Adults
Document Type
article
Author
Sigala, Desiree M; Hieronimus, Bettina; Medici, Valentina; Lee, Vivien; Nunez, Marinelle V; Bremer, Andrew A; Cox, Chad L; Price, Candice A; Benyam, Yanet; Chaudhari, Abhijit J; Abdelhafez, Yasser; McGahan, John P; Goran, Michael; Sirlin, Claude B; Pacini, Giovanni; Tura, Andrea; Keim, Nancy L; Havel, Peter J; Stanhope, Kimber L
Source
The Journal of Clinical Endocrinology & Metabolism. 106(11)
Subject
Language
Abstract
ContextStudies in rodents and humans suggest that high-fructose corn syrup (HFCS)-sweetened diets promote greater metabolic dysfunction than sucrose-sweetened diets.ObjectiveTo compare the effects of consuming sucrose-sweetened beverage (SB), HFCS-SB, or a control beverage sweetened with aspartame on metabolic outcomes in humans.MethodsA parallel, double-blinded, NIH-funded study. Experimental procedures were conducted during 3.5 days of inpatient residence with controlled feeding at a research clinic before (baseline) and after a 12-day outpatient intervention period. Seventy-five adults (18-40 years) were assigned to beverage groups matched for sex, body mass index (18-35 kg/m2), and fasting triglyceride, lipoprotein and insulin concentrations. The intervention was 3 servings/day of sucrose- or HFCS-SB providing 25% of energy requirement or aspartame-SB, consumed for 16 days. Main outcome measures were %hepatic lipid, Matsuda insulin sensitivity index (ISI), and Predicted M ISI.ResultsSucrose-SB increased %hepatic lipid (absolute change: 0.6 ± 0.2%) compared with aspartame-SB (-0.2 ± 0.2%, P