학술논문
Early‐onset Alzheimer's disease shows a distinct neuropsychological profile and more aggressive trajectories of cognitive decline than late‐onset
Document Type
article
Author
Tort‐Merino, Adrià; Falgàs, Neus; Allen, Isabel E; Balasa, Mircea; Olives, Jaume; Contador, José; Castellví, Magdalena; Juncà‐Parella, Jordi; Guillén, Núria; Borrego‐Écija, Sergi; Bosch, Bea; Fernández‐Villullas, Guadalupe; Ramos‐Campoy, Oscar; Antonell, Anna; Rami, Lorena; Sánchez‐Valle, Raquel; Lladó, Albert
Source
Annals of Clinical and Translational Neurology. 9(12)
Subject
Language
Abstract
ObjectivesEarly- and late-onset Alzheimer's disease (EOAD and LOAD) share the same neuropathological traits but show distinct cognitive features. We aimed to explore baseline and longitudinal outcomes of global and domain-specific cognitive function in a well characterized cohort of patients with a biomarker-based diagnosis.MethodsIn this retrospective cohort study, 195 participants were included and classified according to their age, clinical status, and CSF AD biomarker profile: 89 EOAD, 37 LOAD, 46 young healthy controls (age ≤ 65 years), and 23 old healthy controls (>65 years). All subjects underwent clinical and neuropsychological assessment, neuroimaging, APOE genotyping and lumbar puncture.ResultsWe found distinct neuropsychological profiles between EOAD and LOAD at the time of diagnosis. Both groups showed similar performances on memory and language domains, but the EOAD patients displayed worsened deficits in visual perception, praxis, and executive tasks (p