학술논문
Epigenome-wide meta-analysis of BMI in nine cohorts: Examining the utility of epigenetically predicted BMI.
Document Type
article
Author
Do, Whitney; Sun, Dianjianyi; Meeks, Karlijn; Dugué, Pierre-Antoine; Demerath, Ellen; Guan, Weihua; Li, Shengxu; Chen, Wei; Milne, Roger; Adeyemo, Abedowale; Agyemang, Charles; Nassir, Rami; Manson, JoAnn; Hou, Lifang; Horvath, Steve; Assimes, Themistocles; Bhatti, Parveen; Jordahl, Kristina; Baccarelli, Andrea; Smith, Alicia; Staimez, Lisa; Stein, Aryeh; Whitsel, Eric; Narayan, K; Conneely, Karen; Shadyab, Aladdin
Source
American Journal of Human Genetics. 110(2)
Subject
Language
Abstract
This study sought to examine the association between DNA methylation and body mass index (BMI) and the potential of BMI-associated cytosine-phosphate-guanine (CpG) sites to provide information about metabolic health. We pooled summary statistics from six trans-ethnic epigenome-wide association studies (EWASs) of BMI representing nine cohorts (n = 17,034), replicated these findings in the Womens Health Initiative (WHI, n = 4,822), and developed an epigenetic prediction score of BMI. In the pooled EWASs, 1,265 CpG sites were associated with BMI (p