학술논문
Breast Cancer Risk Factors and Survival by Tumor Subtype: Pooled Analyses from the Breast Cancer Association ConsortiumBreast Cancer Risk Factors and Survival By Tumor Subtype
Document Type
article
Author
Morra, Anna; Jung, Audrey Y; Behrens, Sabine; Keeman, Renske; Ahearn, Thomas U; Anton-Culver, Hoda; Arndt, Volker; Augustinsson, Annelie; Auvinen, Päivi K; Freeman, Laura E Beane; Becher, Heiko; Beckmann, Matthias W; Blomqvist, Carl; Bojesen, Stig E; Bolla, Manjeet K; Brenner, Hermann; Briceno, Ignacio; Brucker, Sara Y; Camp, Nicola J; Campa, Daniele; Canzian, Federico; Castelao, Jose E; Chanock, Stephen J; Choi, Ji-Yeob; Clarke, Christine L; Investigators, for the ABCTB; Couch, Fergus J; Cox, Angela; Cross, Simon S; Czene, Kamila; Dörk, Thilo; Dunning, Alison M; Dwek, Miriam; Easton, Douglas F; Eccles, Diana M; Egan, Kathleen M; Evans, D Gareth; Fasching, Peter A; Flyger, Henrik; Gago-Dominguez, Manuela; Gapstur, Susan M; García-Sáenz, José A; Gaudet, Mia M; Giles, Graham G; Grip, Mervi; Guénel, Pascal; Haiman, Christopher A; Håkansson, Niclas; Hall, Per; Hamann, Ute; Han, Sileny N; Hart, Steven N; Hartman, Mikael; Heyworth, Jane S; Hoppe, Reiner; Hopper, John L; Hunter, David J; Ito, Hidemi; Jager, Agnes; Jakimovska, Milena; Jakubowska, Anna; Janni, Wolfgang; Kaaks, Rudolf; Kang, Daehee; Kapoor, Pooja Middha; Kitahara, Cari M; Koutros, Stella; Kraft, Peter; Kristensen, Vessela N; Collaborators, for the NBCS; Lacey, James V; Lambrechts, Diether; Le Marchand, Loic; Li, Jingmei; Lindblom, Annika; Lubiński, Jan; Lush, Michael; Mannermaa, Arto; Manoochehri, Mehdi; Margolin, Sara; Mariapun, Shivaani; Matsuo, Keitaro; Mavroudis, Dimitrios; Milne, Roger L; Muranen, Taru A; Newman, William G; Noh, Dong-Young; Nordestgaard, Børge G; Obi, Nadia; Olshan, Andrew F; Olsson, Håkan; Park-Simon, Tjoung-Won; Petridis, Christos; Pharoah, Paul DP; Plaseska-Karanfilska, Dijana; Presneau, Nadege; Rashid, Muhammad U; Rennert, Gad; Rennert, Hedy S; Rhenius, Valerie
Source
Cancer Epidemiology Biomarkers & Prevention. 30(4)
Subject
Language
Abstract
BackgroundIt is not known whether modifiable lifestyle factors that predict survival after invasive breast cancer differ by subtype.MethodsWe analyzed data for 121,435 women diagnosed with breast cancer from 67 studies in the Breast Cancer Association Consortium with 16,890 deaths (8,554 breast cancer specific) over 10 years. Cox regression was used to estimate associations between risk factors and 10-year all-cause mortality and breast cancer-specific mortality overall, by estrogen receptor (ER) status, and by intrinsic-like subtype.ResultsThere was no evidence of heterogeneous associations between risk factors and mortality by subtype (P adj > 0.30). The strongest associations were between all-cause mortality and BMI ≥30 versus 18.5-25 kg/m2 [HR (95% confidence interval (CI), 1.19 (1.06-1.34)]; current versus never smoking [1.37 (1.27-1.47)], high versus low physical activity [0.43 (0.21-0.86)], age ≥30 years versus 0-