학술논문
Early Pregnancy Atherogenic Profile in a First Pregnancy and Hypertension Risk 2 to 7 Years After Delivery
Document Type
article
Author
Catov, Janet M; McNeil, Rebecca B; Marsh, Derek J; Mercer, Brian M; Merz, C Noel Bairey; Parker, Corette B; Pemberton, Victoria L; Saade, George R; Chen, Yii‐Der; Chung, Judith H; Ehrenthal, Deborah B; Grobman, William A; Haas, David M; Parry, Samuel; Polito, LuAnn; Reddy, Uma M; Silver, Robert M; Simhan, Hyagriv N; Wapner, Ronald J; Kominiarek, Michelle; Kreutz, Rolf; Levine, Lisa D; Greenland, Philip; Study, for the NHLBI nuMoM2b Heart Health
Source
Journal of the American Heart Association. 10(5)
Subject
Language
Abstract
Background Cardiovascular risk in young adulthood is an important determinant of lifetime cardiovascular disease risk. Women with adverse pregnancy outcomes (APOs) have increased cardiovascular risk, but the relationship of other factors is unknown. Methods and Results Among 4471 primiparous women, we related first-trimester atherogenic markers to risk of APO (hypertensive disorders of pregnancy, preterm birth, small for gestational age), gestational diabetes mellitus (GDM) and hypertension (130/80 mm Hg or antihypertensive use) 2 to 7 years after delivery. Women with an APO/GDM (n=1102) had more atherogenic characteristics (obesity [34.2 versus 19.5%], higher blood pressure [systolic blood pressure 112.2 versus 108.4, diastolic blood pressure 69.2 versus 66.6 mm Hg], glucose [5.0 versus 4.8 mmol/L], insulin [77.6 versus 60.1 pmol/L], triglycerides [1.4 versus 1.3 mmol/L], and high-sensitivity C-reactive protein [5.6 versus 4.0 nmol/L], and lower high-density lipoprotein cholesterol [1.8 versus 1.9 mmol/L]; P