학술논문

Sphingolipid Metabolic Pathway Impacts Thiazide Diuretics Blood Pressure Response: Insights From Genomics, Metabolomics, and Lipidomics

Document Type

article

Author

Shahin, Mohamed H; Gong, Yan; Frye, Reginald F; Rotroff, Daniel M; Beitelshees, Amber L; Baillie, Rebecca A; Chapman, Arlene B; Gums, John G; Turner, Stephen T; Boerwinkle, Eric; Motsinger‐Reif, Alison; Fiehn, Oliver; Cooper‐DeHoff, Rhonda M; Han, Xianlin; Kaddurah‐Daouk, Rima; Johnson, Julie A

Source

Journal of the American Heart Association. 7(1)

Subject

Human Genome
Genetics
Hypertension
Biotechnology
2.1 Biological and endogenous factors
Aetiology
Cardiovascular
Adult
Blood Pressure
Female
Genomics
Humans
Hydrochlorothiazide
Lipid Metabolism
Male
Metabolic Networks and Pathways
Metabolomics
Middle Aged
Nitriles
Pharmacogenetics
Prognosis
Serine C-Palmitoyltransferase
Siloxanes
Sodium Chloride Symporter Inhibitors
Sphingolipids
Treatment Outcome
blood pressure
lipid metabolites
metabolomics
pharmacogenetics
thiazide diuretics
Cardiorespiratory Medicine and Haematology

Language

Abstract

Although hydrochlorothiazide (HCTZ) is a well-established first-line antihypertensive in the United States,

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