학술논문

Symptoms of Women With High-Risk Early-Stage Ovarian Cancer
Document Type
article
Source
Obstetrics and Gynecology. 139(2)
Subject
Rare Diseases
Pain Research
Prevention
Ovarian Cancer
Chronic Pain
Cancer
Clinical Trials and Supportive Activities
Clinical Research
Early Diagnosis
Female
Humans
Middle Aged
Ovarian Neoplasms
Ovary
Retrospective Studies
United States
Paediatrics and Reproductive Medicine
Obstetrics & Reproductive Medicine
Language
Abstract
ObjectiveTo assess the presentation, characteristics, and prognostic significance of symptoms in patients with high-risk early-stage epithelial ovarian cancer.MethodsA retrospective chart review was performed on all patients enrolled in a phase III clinical trial (GOG 157). All patients had surgically staged, high-risk early-stage epithelial ovarian cancer (stage IA-IB and grade 3, any clear cell, stage IC or II). Chi-square and Kaplan-Meier estimates and Cox proportional hazards models were used for statistical analyses.ResultsOf 419 patients evaluated for symptoms, 301 (72%) presented with one or more symptoms, and 118 (28%) were asymptomatic but had a mass found on examination. Forty percent had only one symptom, and 32% had more than one symptom. Among those with at least one symptom, the most common were abdominal and pelvic pain (31%), and increased girth or fullness (26%). Overall, 23% of patients with tumors 10 cm or smaller, 27% of patients with tumors larger than 10 cm to 15 cm, and 46% of patients with tumors larger than 15 cm had multiple symptoms (P