학술논문

Defining necrotizing enterocolitis: current difficulties and future opportunities
Document Type
article
Source
Pediatric Research. 88(Suppl 1)
Subject
Rare Diseases
Pediatric
Orphan Drug
Perinatal Period - Conditions Originating in Perinatal Period
Infant Mortality
Preterm
Low Birth Weight and Health of the Newborn
Good Health and Well Being
Centers for Disease Control and Prevention
U.S.
Consensus
Enterocolitis
Necrotizing
Female
Humans
Infant
Infant
Newborn
Infant
Newborn
Diseases
Infant
Premature
Infant
Premature
Diseases
Male
Neonatology
Risk
Risk Factors
United Kingdom
United States
Paediatrics and Reproductive Medicine
Public Health and Health Services
Pediatrics
Language
Abstract
Necrotizing enterocolitis (NEC) is a leading cause of morbidity and mortality in hospitalized infants. First classified through Bell staging in 1978, a number of additional definitions of NEC have been proposed in the subsequent decades. In this review, we summarize eight current definitions of NEC, and explore similarities and differences in clinical signs and radiographic features included within these definitions, as well as their limitations. We highlight the importance of a global consensus on defining NEC to improve NEC research and outcomes, incorporating input from participants at an international NEC conference. We also highlight the important role of patient-families in helping to redefine NEC.