학술논문
Menopausal hormone therapy prior to the diagnosis of ovarian cancer is associated with improved survival
Document Type
article
Author
Brieger, Katharine K; Peterson, Siri; Lee, Alice W; Mukherjee, Bhramar; Bakulski, Kelly M; Alimujiang, Aliya; Anton-Culver, Hoda; Anglesio, Michael S; Bandera, Elisa V; Berchuck, Andrew; Bowtell, David DL; Chenevix-Trench, Georgia; Cho, Kathleen R; Cramer, Daniel W; DeFazio, Anna; Doherty, Jennifer A; Fortner, Renée T; Garsed, Dale W; Gayther, Simon A; Gentry-Maharaj, Aleksandra; Goode, Ellen L; Goodman, Marc T; Harris, Holly R; Høgdall, Estrid; Huntsman, David G; Shen, Hui; Jensen, Allan; Johnatty, Sharon E; Jordan, Susan J; Kjaer, Susanne K; Kupryjanczyk, Jolanta; Lambrechts, Diether; McLean, Karen; Menon, Usha; Modugno, Francesmary; Moysich, Kirsten; Ness, Roberta; Ramus, Susan J; Richardson, Jean; Risch, Harvey; Rossing, Mary Anne; Trabert, Britton; Wentzensen, Nicolas; Ziogas, Argyrios; Terry, Kathryn L; Wu, Anna H; Hanley, Gillian E; Pharoah, Paul; Webb, Penelope M; Pike, Malcolm C; Pearce, Celeste Leigh; Consortium, for the Ovarian Cancer Association
Source
Gynecologic Oncology. 158(3)
Subject
Language
Abstract
PurposePrior studies of menopausal hormone therapy (MHT) and ovarian cancer survival have been limited by lack of hormone regimen detail and insufficient sample sizes. To address these limitations, a comprehensive analysis of 6419 post-menopausal women with pathologically confirmed ovarian carcinoma was conducted to examine the association between MHT use prior to diagnosis and survival.MethodsData from 15 studies in the Ovarian Cancer Association Consortium were included. MHT use was examined by type (estrogen-only (ET) or estrogen+progestin (EPT)), duration, and recency of use relative to diagnosis. Cox proportional hazards models were used to estimate the association between hormone therapy use and survival. Logistic regression and mediation analysis was used to explore the relationship between MHT use and residual disease following debulking surgery.ResultsUse of ET or EPT for at least five years prior to diagnosis was associated with better ovarian cancer survival (hazard ratio, 0.80; 95% CI, 0.74 to 0.87). Among women with advanced stage, high-grade serous carcinoma, those who used MHT were less likely to have any macroscopic residual disease at the time of primary debulking surgery (p for trend