학술논문

The mammalian gene function resource: the International Knockout Mouse Consortium.
Document Type
article
Author
Bradley, AllanAnastassiadis, KonstantinosAyadi, AbdelkaderBattey, James FBell, CindyBirling, Marie-ChristineBottomley, JoannaBrown, Steve DBürger, AntjeBult, Carol JBushell, WendyCollins, Francis SDesaintes, ChristianDoe, BrendanEconomides, ArisEppig, Janan TFinnell, Richard HFletcher, ColinFray, MartinFrendewey, DavidFriedel, Roland HGrosveld, Frank GHansen, JensHérault, YannHicks, GeoffreyHörlein, AndreasHoughton, RichardHrabé de Angelis, MartinHuylebroeck, DannyIyer, Vivekde Jong, Pieter JKadin, James AKaloff, CorneliaKennedy, KarenKoutsourakis, ManousosLloyd, KC KentMarschall, SusanMason, JeremyMcKerlie, ColinMcLeod, Michael Pvon Melchner, HaraldMoore, MarkMujica, Alejandro ONagy, AndrasNefedov, MikhailNutter, Lauryl MPavlovic, GuillaumePeterson, Jane LPollock, JonathanRamirez-Solis, RamiroRancourt, Derrick ERaspa, MarcelloRemacle, Jacques ERingwald, MartinRosen, BarryRosenthal, NadiaRossant, JanetRuiz Noppinger, PatriciaRyder, EdSchick, Joel ZupicichSchnütgen, FrankSchofield, PaulSeisenberger, ClaudiaSelloum, MohammedSimpson, Elizabeth MSkarnes, William CSmedley, DamianStanford, William LStewart, A FrancisStone, KevinSwan, KateTadepally, HamsaTeboul, LydiaTocchini-Valentini, Glauco PValenzuela, DavidWest, Anthony PYamamura, Ken-ichiYoshinaga, YukoWurst, Wolfgang
Source
Mammalian genome : official journal of the International Mammalian Genome Society. 23(9-10)
Subject
Animals
Mice
Knockout
Mice
Internationality
Internet
Knockout
Genetics
Genetics & Heredity
Language
Abstract
In 2007, the International Knockout Mouse Consortium (IKMC) made the ambitious promise to generate mutations in virtually every protein-coding gene of the mouse genome in a concerted worldwide action. Now, 5 years later, the IKMC members have developed high-throughput gene trapping and, in particular, gene-targeting pipelines and generated more than 17,400 mutant murine embryonic stem (ES) cell clones and more than 1,700 mutant mouse strains, most of them conditional. A common IKMC web portal (www.knockoutmouse.org) has been established, allowing easy access to this unparalleled biological resource. The IKMC materials considerably enhance functional gene annotation of the mammalian genome and will have a major impact on future biomedical research.