학술논문
Serum biomarkers correlated with liver stiffness assessed in a multicenter study of pediatric cholestatic liver disease
Document Type
article
Author
Leung, Daniel H; Devaraj, Sridevi; Goodrich, Nathan P; Chen, Xinpu; Rajapakshe, Deepthi; Ye, Wen; Andreev, Victor; Minard, Charles G; Guffey, Danielle; Molleston, Jean P; Bass, Lee M; Karpen, Saul J; Kamath, Binita M; Wang, Kasper S; Sundaram, Shikha S; Rosenthal, Philip; McKiernan, Patrick; Loomes, Kathleen M; Jensen, M Kyle; Horslen, Simon P; Bezerra, Jorge A; Magee, John C; Merion, Robert M; Sokol, Ronald J; Shneider, Benjamin L; Network, The Childhood Liver Disease Research; Alonso, Estella; Bass, Lee; Kelly, Susan; Riordan, Mary; Melin‐Aldana, Hector; Bezerra, Jorge; Bove, Kevin; Heubi, James; Miethke, Alexander; Tiao, Greg; Denlinger, Julie; Chapman, Erin; Sokol, Ronald; Feldman, Amy; Mack, Cara; Narkewicz, Michael; Suchy, Frederick; Van Hove, Johan; Garcia, Benigno; Kauma, Mikaela; Kocher, Kendra; Steinbeiss, Matthew; Lovell, Mark; Piccoli, David; Rand, Elizabeth; Russo, Pierre; Spinner, Nancy; Erlichman, Jessi; Stalford, Samantha; Pakstis, Dina; King, Sakya; Squires, Robert; Sindhi, Rakesh; Venkat, Veena; Bukauskas, Kathy; Haberstroh, Lori; Squires, James; Bull, Laura; Curry, Joanna; Langlois, Camille; Kim, Grace; Teckman, Jeffery; Kociela, Vikki; Nagy, Rosemary; Patel, Shraddha; Cerkoski, Jacqueline; Bozic, Molly; Subbarao, Girish; Klipsch, Ann; Sawyers, Cindy; Cummings, Oscar; Murray, Karen; Hsu, Evelyn; Cooper, Kara; Young, Melissa; Finn, Laura; Ng, Vicky; Quammie, Claudia; Putra, Juan; Sharma, Deepika; Parmar, Aishwarya; Guthery, Stephen; Jensen, Kyle; Rutherford, Ann; Lowichik, Amy; Book, Linda; Meyers, Rebecka
Source
Hepatology. 77(2)
Subject
Language
Abstract
Background and aimsDetailed investigation of the biological pathways leading to hepatic fibrosis and identification of liver fibrosis biomarkers may facilitate early interventions for pediatric cholestasis.Approach and resultsA targeted enzyme-linked immunosorbent assay-based panel of nine biomarkers (lysyl oxidase, tissue inhibitor matrix metalloproteinase (MMP) 1, connective tissue growth factor [CTGF], IL-8, endoglin, periostin, Mac-2-binding protein, MMP-3, and MMP-7) was examined in children with biliary atresia (BA; n = 187), alpha-1 antitrypsin deficiency (A1AT; n = 78), and Alagille syndrome (ALGS; n = 65) and correlated with liver stiffness (LSM) and biochemical measures of liver disease. Median age and LSM were 9 years and 9.5 kPa. After adjusting for covariates, there were positive correlations among LSM and endoglin ( p = 0.04) and IL-8 ( p