학술논문
Stability of Colistimethate Sodium in Aqueous Solution
Document Type
article
Author
Source
Antimicrobial Agents and Chemotherapy. 56(12)
Subject
Language
Abstract
Colistimethate sodium, increasingly used to treat multidrug-resistant Gram-negative infections, spontaneously hydrolyzes to form colistin A (polymyxin E1) and B (polymyxin E2/B) when mixed with water. High levels of these active breakdown products at the time of administration have been associated with nephrotoxicity and even death. In this study, reconstituted colistimethate sodium was shown to be stable (