학술논문
The Association between Peptic Ulcer Disease and Gastric Cancer: Results from the Stomach Cancer Pooling (StoP) Project Consortium
Document Type
article
Author
Paragomi, Pedram; Dabo, Bashir; Pelucchi, Claudio; Bonzi, Rossella; Bako, Abdulaziz T; Sanusi, Nabila Muhammad; Nguyen, Quan H; Zhang, Zuo-Feng; Palli, Domenico; Ferraroni, Monica; Vu, Khanh Truong; Yu, Guo-Pei; Turati, Federica; Zaridze, David; Maximovitch, Dmitry; Hu, Jinfu; Mu, Lina; Boccia, Stefania; Pastorino, Roberta; Tsugane, Shoichiro; Hidaka, Akihisa; Kurtz, Robert C; Lagiou, Areti; Lagiou, Pagona; Camargo, M Constanza; Curado, Maria Paula; Lunet, Nuno; Vioque, Jesus; Boffetta, Paolo; Negri, Eva; La Vecchia, Carlo; Luu, Hung N
Source
Cancers. 14(19)
Subject
Language
Abstract
BackgroundGastric cancer (GC) is the fifth most common type of cancer and the fourth most common cause of cancer-related mortality. Although the risk of GC and peptic ulcer disease (PUD) is known to be increased by H. pylori infection, evidence regarding the direct relationship between PUD and GC across ethnicities is inconclusive. Therefore, we investigated the association between PUD and GC in the Stomach cancer Pooling (StoP) consortium.MethodsHistory of peptic ulcer disease was collected using a structured questionnaire in 11 studies in the StoP consortium, including 4106 GC cases and 6922 controls. The two-stage individual-participant data meta-analysis approach was adopted to generate a priori. Unconditional logistic regression and Firth's penalized maximum likelihood estimator were used to calculate study-specific odds ratios (ORs) and 95% confidence intervals (CIs) for the association between gastric ulcer (GU)/duodenal ulcer (DU) and risk of GC.ResultsHistory of GU and DU was thoroughly reported and used in association analysis, respectively, by 487 cases (12.5%) and 276 controls (4.1%), and 253 cases (7.8%) and 318 controls (6.0%). We found that GU was associated with an increased risk of GC (OR = 3.04, 95% CI: 2.07-4.49). No association between DU and GC risk was observed (OR = 1.03, 95% CI: 0.77-1.39).ConclusionsIn the pooled analysis of 11 case-control studies in a large consortium (i.e., the Stomach cancer Pooling (StoP) consortium), we found a positive association between GU and risk of GC and no association between DU and GC risk.