학술논문
A multiancestry genome-wide association study of unexplained chronic ALT elevation as a proxy for nonalcoholic fatty liver disease with histological and radiological validation
Document Type
article
Author
Vujkovic, Marijana; Ramdas, Shweta; Lorenz, Kim M; Guo, Xiuqing; Darlay, Rebecca; Cordell, Heather J; He, Jing; Gindin, Yevgeniy; Chung, Chuhan; Myers, Robert P; Schneider, Carolin V; Park, Joseph; Lee, Kyung Min; Serper, Marina; Carr, Rotonya M; Kaplan, David E; Haas, Mary E; MacLean, Matthew T; Witschey, Walter R; Zhu, Xiang; Tcheandjieu, Catherine; Kember, Rachel L; Kranzler, Henry R; Verma, Anurag; Giri, Ayush; Klarin, Derek M; Sun, Yan V; Huang, Jie; Huffman, Jennifer E; Creasy, Kate Townsend; Hand, Nicholas J; Liu, Ching-Ti; Long, Michelle T; Yao, Jie; Budoff, Matthew; Tan, Jingyi; Li, Xiaohui; Lin, Henry J; Chen, Yii-Der Ida; Taylor, Kent D; Chang, Ruey-Kang; Krauss, Ronald M; Vilarinho, Silvia; Brancale, Joseph; Nielsen, Jonas B; Locke, Adam E; Jones, Marcus B; Verweij, Niek; Baras, Aris; Reddy, K Rajender; Neuschwander-Tetri, Brent A; Schwimmer, Jeffrey B; Sanyal, Arun J; Chalasani, Naga; Ryan, Kathleen A; Mitchell, Braxton D; Gill, Dipender; Wells, Andrew D; Manduchi, Elisabetta; Saiman, Yedidya; Mahmud, Nadim; Miller, Donald R; Reaven, Peter D; Phillips, Lawrence S; Muralidhar, Sumitra; DuVall, Scott L; Lee, Jennifer S; Assimes, Themistocles L; Pyarajan, Saiju; Cho, Kelly; Edwards, Todd L; Damrauer, Scott M; Wilson, Peter W; Gaziano, J Michael; O’Donnell, Christopher J; Khera, Amit V; Grant, Struan FA; Brown, Christopher D; Tsao, Philip S; Saleheen, Danish; Lotta, Luca A; Bastarache, Lisa; Anstee, Quentin M; Daly, Ann K; Meigs, James B; Rotter, Jerome I; Lynch, Julie A; Rader, Daniel J; Voight, Benjamin F; Chang, Kyong-Mi
Source
Nature Genetics. 54(6)
Subject
Language
Abstract
Nonalcoholic fatty liver disease (NAFLD) is a growing cause of chronic liver disease. Using a proxy NAFLD definition of chronic elevation of alanine aminotransferase (cALT) levels without other liver diseases, we performed a multiancestry genome-wide association study (GWAS) in the Million Veteran Program (MVP) including 90,408 cALT cases and 128,187 controls. Seventy-seven loci exceeded genome-wide significance, including 25 without prior NAFLD or alanine aminotransferase associations, with one additional locus identified in European American-only and two in African American-only analyses (P