학술논문
High incidence of proliferative and membranous nephritis in SLE patients with low proteinuria in the Accelerating Medicines Partnership.
Document Type
article
Author
Carlucci, Philip M; Li, Jessica; Fava, Andrea; Deonaraine, Kristina K; Wofsy, David; James, Judith A; Putterman, Chaim; Diamond, Betty; Davidson, Anne; Fine, Derek M; Monroy-Trujillo, Jose; Atta, Mohamed G; DeJager, Wade; Guthridge, Joel M; Haag, Kristin; Rao, Deepak A; Brenner, Michael B; Lederer, James A; Apruzzese, William; Belmont, H Michael; Izmirly, Peter M; Zaminski, Devyn; Wu, Ming; Connery, Sean; Payan-Schober, Fernanda; Furie, Richard; Dall’Era, Maria; Cho, Kerry; Kamen, Diane; Kalunian, Kenneth; Anolik, Jennifer; Barnas, Jennifer; Ishimori, Mariko; Weisman, Michael H; Goff, Jennifer; Dunn, Patrick J; Raychaudhuri, Soumya; Zhang, Fan; Korsunsky, Ilya; Nathan, Aparna; Mears, Joseph; Ishigaki, Kazuyoshi; Xiao, Qian; Millard, Nghia; Weinand, Kathryn; Sakaue, Saori; Utz, PJ; Mao, Rong; Robinson, Bill; Maecker, Holden; Macwana, Susan; Bridges, S Louis; Bykerk, Vivian; Donlin, Laura; Goodman, Susan; DiCarlo, Edward; Smith, Melanie; Lakhanpal, Amit; Sherman, Heather; Singaraju, Anvita; Shakib, Lorien; Ritchlin, Christopher; Boyce, Brendan; Tabechian, Darren; McDavid, Andrew; Rangel-Moreno, Javier; Meednu, Nida; Albrecht, Jen; Wei, Kevin; Helena Jonsson, A; Simmons, Daimon; Keras, Gregory; Keegan, Joshua; Watts, Gerald; Li Zhu, Yuhong; Chicoine, Adam; Jian Li, Zhihan; Gravallese, Ellen M; Howard, Kaitlyn; McGeachy, Mandy; Firestein, Gary S; Boyle, David L; Ceponis, Arnold; Gregersen, Peter K; Horowitz, Diane; Perlman, Harris; Dominguez, Salina; Cuda, Carla M; Mandolin, Arthur M; Thakrar, Anjali; Bathon, Joan M; Hughes, Laura; Michael Holers, V; Seifert, Jennifer; Deane, Kevin; Moreland, Larry W; Filer, Andrew; Raza, Karim; Sahbudin, Ilfita; Pitzalis, Costantino
Source
Rheumatology. 61(11)
Subject
Language
Abstract
ObjectiveDelayed detection of LN associates with worse outcomes. There are conflicting recommendations regarding a threshold level of proteinuria at which biopsy will likely yield actionable management. This study addressed the association of urine protein:creatinine ratios (UPCR) with clinical characteristics and investigated the incidence of proliferative and membranous histology in patients with a UPCR between 0.5 and 1.MethodsA total of 275 SLE patients (113 first biopsy, 162 repeat) were enrolled in the multicentre multi-ethnic/racial Accelerating Medicines Partnership across 15 US sites at the time of a clinically indicated renal biopsy. Patients were followed for 1 year.ResultsAt biopsy, 54 patients had UPCR