학술논문
Convection-enhanced delivery of AAV2-PrPshRNA in prion-infected mice.
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article
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Abstract
Prion disease is caused by a single pathogenic protein (PrPSc), an abnormal conformer of the normal cellular prion protein PrPC. Depletion of PrPC in prion knockout mice makes them resistant to prion disease. Thus, gene silencing of the Prnp gene is a prom