부산대학교 도서관

Removal of 'spare' proteins Membrane proteins that fail to be delivered to the endoplasmic reticulum must be rapidly degraded to avoid inappropriate aggregation and disruption of protein homeostasis. The mechanism of this process of mislocalized protein (MLP) degradation is unknown. Here Bag6, a chaperone complex involved in protein targeting, is identified as part of this mechanism. Bag6 interacts with and captures MLPs, coupling them to the ubiquitin-mediated degradation pathway. This could potentially achieve rapid degradation of MLPs without futile engagement of the cytosolic folding machinery.