학술논문
The Ter mutation in the dead end gene causes germ cell loss and testicular germ cell tumours
Document Type
redif-article
Author
Source
Nature, Nature. 435(7040):360-364
Subject
Language
English
Abstract
Testicular cancer The phenotype of Ter testicular germ cell tumour susceptibility gene was first described more than 30 years ago, but it has taken until now for the identity of the gene to be discovered. Ter is a mutation inducing a termination codon on the mouse version of the dead end gene, known from zebrafish embryos. It encodes a protein with an RNA recognition motif, thus implicating RNA biology in testicular tumour development.