학술논문
The haplotype-resolved genome and epigenome of the aneuploid HeLa cancer cell line
Document Type
redif-article
Author
Source
Nature, Nature. 500(7461):207-211
Subject
Language
English
Abstract
Haplotype-resolved whole-genome sequencing of the HeLa CCL-2 strain shows that HeLa is relatively stable in terms of point variation; integration of several data sets reveals strong, haplotype-specific activation of the proto-oncogene MYC by the human papilloma virus type 18 genome, and enables the relationship between gene dosage and expression to be examined.