부산대학교 도서관

Necrosis recognition linked to immunity Necrotic cell corpses accumulate in tissues as a result of injury or impaired clearance of apoptotic cells, and can induce an inflammatory response that initiates tissue repair. The recently described dendritic C-type lectin receptor CLEC9A, also called DNGR-1, is shown to sense necrotic debris by recognizing a preformed signal that is exposed on necrotic cells, and to mediate cross presentation of dead cell-associated antigens.