학술논문
Novel role of PKR in inflammasome activation and HMGB1 release
Document Type
redif-article
Author
Source
Nature, Nature. 488(7413):670-674
Subject
Language
English
Abstract
Double-stranded RNA-dependent protein kinase (PKR) is shown to be a key regulator of the inflammasome; PKR is central for caspase-1 activation and the release of interleukin (IL)-1β, IL-18 and high-mobility group box 1 (HMGB1) in response to a diverse range of stimuli.