학술논문
TRIM5 is an innate immune sensor for the retrovirus capsid lattice
Document Type
redif-article
Author
Source
Nature, Nature. 472(7343):361-365
Subject
Language
English
Abstract
Multi-layered antiviral activity of TRIM5 TRIM5 is an E3 ubiquitin ligase with known antiretroviral restriction factor activity, although the mechanisms involved are poorly understood. Luban and colleagues now demonstrate that TRIM5 activates innate immune signalling pathways and acts as a pattern recognition receptor specific for the retrovirus capsid lattice.