학술논문
Deubiquitinase DUBA is a post-translational brake on interleukin-17 production in T cells
Document Type
redif-article
Author
Source
Nature, Nature. 518(7539):417-421
Subject
Language
English
Abstract
The deubiquitinase enzyme DUBA is shown to act as a negative regulator of interleukin-17A (IL-17A) in TH17 cells; DUBA interacts with and stabilizes the ubiquitin ligase UBR5, which in turn targets RORγt for degradation in the proteaseome, thus limiting IL-17A production.