학술논문
Insulin compounds and compositions
Document Type
Patent
Author
Source
Subject
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Abstract
Novel insulin compounds having a desirably protracted insulin action and/or antigenicity are provided.
The novel insulin compounds are represented by the formula II: ##STR1## wherein E individually represents Glu or a neutral amino acid residue which can be coded for by nucleotide sequences, N represents an amino acid residue which can be coded for by nucleotide sequences
T represents Thr or Arg
X represents Thr, Ser, Ala or OH, and
Y represents OR or NR.sup.1 R.sup.2, where R, R.sup.1 and R.sup.2 individually represents hydrogen or lower alkyl, but is not present when X represents OH.
The novel insulin compounds are represented by the formula II: ##STR1## wherein E individually represents Glu or a neutral amino acid residue which can be coded for by nucleotide sequences, N represents an amino acid residue which can be coded for by nucleotide sequences
T represents Thr or Arg
X represents Thr, Ser, Ala or OH, and
Y represents OR or NR.sup.1 R.sup.2, where R, R.sup.1 and R.sup.2 individually represents hydrogen or lower alkyl, but is not present when X represents OH.