학술논문
Oxidative stress status and DNA damage in saliva of human subjects with oral lichen planus and oral squamous cell carcinoma
Document Type
Academic Journal
Source
Journal of Oral Pathology & Medicine. Nov 01, 2012 41(10):736-740
Subject
Language
English
ISSN
0904-2512
Abstract
BACKGROUND:: METHODS:: Thirty-two patients with OLP, 26 patients with OSCC, and 30 non-involved subjects were enrolled in this study. The study was conducted at the Cancer Department, Clinic of Oral Medicine, Tehran University of Medical Sciences. The unstimulated whole saliva malondialdehyde (MDA), as an indicator of lipid peroxidation, the total antioxidant capacity (TAC), and 8-hydroxy-2′-deoxyguanosine (8-OHdG) were assayed by thiobarbituric acid, ferric reducing antioxidant potential (FRAP), and ELISA method, respectively. The TAC/MDA ratio was used as an index of oxidative stress status. Data were analyzed by ANOVA followed by the Tukeyʼs post hoc test. RESULTS AND CONCLUSION:: J Oral Pathol Med (2012) 41: 736–740