학술논문
Pallidal stimulation for cervical dystonia does not correct abnormal temporal discrimination
Document Type
Academic Journal
Author
Sadnicka, Anna; Kimmich, Okka; Pisarek, Claudia; Ruge, Diane; Galea, Joe; Kassavetis, Panagiotis; Pareés, Isabel; Saifee, Tabish; Molloy, Anna; Bradley, David; OʼRiordan, Sean; Zrinzo, Ludvic; Hariz, Marwan; Bhatia, Kailash P.; Limousin, Patricia; Foltynie, Thomas; Rothwell, John C.; Hutchinson, Michael; Edwards, Mark J.
Source
Movement Disorders. Nov 01, 2013 28(13):1874-1877
Subject
Language
English
ISSN
0885-3185
Abstract
BACKGROUND:: We investigated whether clinical improvement observed after deep brain stimulation (DBS) of the globus pallidus internus (GPi) in cervical dystonia (CD) is paralleled by the normalisation of temporal discrimination thresholds (TDTs), a marker of abnormal sensory processing in CD. METHODS:: TDT was tested in 11 patients with CD after they received DBS and was compared with TDT scores from 24 patients with CD and a group of 61 controls. RESULTS:: A clear clinical response to GPi-DBS was demonstrated (total Toronto Western Spasmodic Torticollis Rating Scale scores fell from 50 to 18; P < 0.001). In contrast, TDT remained abnormal in the CD-DBS group (P < 0.001) and was not significantly different from the abnormal TDT range observed in CD. CONCLUSIONS:: Underlying sensory abnormalities in temporal discrimination observed in dystonia do not seem to be corrected by successful GPi-DBS. This adds further data to the ongoing debate regarding which pathophysiological abnormalities observed in dystonia are likely to be causal in the genesis of the disease rather than epiphenomena observed secondary to abnormal motor activity. © 2013 International Parkinson and Movement Disorder Society