학술논문
Content of Apoptotic Enzyme Caspase-3 mRNA in Brain Stem and Cortex in Rats during Postnatal Ontogeny
Document Type
Academic Journal
Author
Source
Bulletin of Experimental Biology & Medicine. Aug 01, 2001 132(2):748-750
Subject
Language
English
ISSN
0007-4888
Abstract
The content of caspase-3 mRNA in rat brain stem decreased from birth to postnatal week 3 and dropped below reverse transcription-PCR sensitivity limit in 1.5-month-old animals. The number of brain stem cells in 2-40-day-old rats was constant. The content of caspase-3 mRNA in the cortex was higher than in the brain stem and decreased by one-third by postnatal day 40. The number of cells in the cortex decreased 2-fold during postnatal week 1 and then remained unchanged. Changes in the content of caspase-3 mRNA did not correlate directly with variations in the number of brain cells during postnatal ontogeny.