부산대학교 도서관

Introduction: Little is known about the incidence and impact of infective complication on clinical outcomes in patients with acute ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI).Hypothesis: Whether the infective complication influences the in hospital mortality or major adverse cardiovascular events (MACEs) in STEMI patients undergoing primary PCI.Methods: We prospectively enrolled 2284 STEMI patients undergoing primary PCI between January 2010 and June 2016. Detailed information on infection was collected for all patients. Multivariate analysis was performed to assess the clinical outcomes among patients with and without infections after adjusting for associated clinical variables. MACEs included in hospital mortality, or target vessel revascularization, or re-myocardial infraction, or cerebrovascular events.Results: Overall, 459 patients developed an infection (20.1%), most of whom presented with a single-site infection. The most commonly identified organism was pneumonia infection. Patients complicated infections had more comorbidities than those without infections (hypertension: 60.1% vs. 50.1%; diabetes mellitus: 36.6% vs. 24.3%; chronic lung disease: 1.6% vs. 0.6%; p<0.05, respectively=. Furthermore, patients complicated with infection were related to significantly higher incidences of in hospital mortality (adjusted odds ratio [OR]: 6.2; 95% confidence interval [CI]: 3.9 to 9.7, p<0.001) and MACEs (adjusted OR: 6.9; 95% CI: 4.6 to 10.2, p<0.001=.Conclusions: Patients with STEMI complicated with infections were common and related to markedly worse in hospital clinical outcomes. Strategies for early identifying these high-risk patients and reducing their risk of infection are warranted.