학술논문
Autoregulation of Cerebral Blood Flow is Preserved in Primary Intracerebral Hemorrhage
Document Type
Academic Journal
Author
Source
Stroke. Jun 01, 2013 44(6):1726-1728
Subject
Language
English
ISSN
0039-2499
Abstract
BACKGROUND AND PURPOSE—: Treatment of acute hypertension after intracerebral hemorrhage (ICH) is controversial. In the context of disrupted cerebral autoregulation, blood pressure (BP) reduction may cause decreased cerebral blood flow (CBF). We used serial computed tomography perfusion to test the hypothesis that CBF remains stable after BP reduction. METHODS—: Patients recruited within 72 hours of ICH were imaged with computed tomography perfusion before and after BP treatment. Change in perihematoma relative (r) CBF after BP treatment was the primary end point. RESULTS—: Twenty patients were imaged with computed tomography perfusion at a median (interquartile range) time from onset of 20.2 (25.7) hours and reimaged 2.1 (0.5) hours later, after BP reduction. Mean systolic BP in treated patients (n=16; 4 untreated as BP