부산대학교 도서관

BACKGROUND:: Biphasic calcium phosphate (BCP)/poly L-lactic acid (PLLA) composite material has good bioactivity and bio-degradation. BCP with proper porous structure has an osteo-inductivity. Compared with the well-reported hydroxyapatite (HA)/PLLA, BCP/PLLA composite is expected to be a promising bone repairing material. OBJECTIVE:: To prepare BCP/PLLA composite and evaluate its biocompatibility. DESIGN, TIME AND SETTING: Material preparation and animal experiment was performed in College of Materials Science and Engineering, Sichuan University and West China College of Stomatology, Sichuan University from March and December 2008. Some tests were performed in General Hospital of Chengdu Military Area Command of Chinese PLA. MATERIALS:: BCP/PLLA composite with porous structure was prepared using solvent casting/particulate leaching technique. METHODS:: The biocompatibility of the material was evaluated by implantation in muscle, dermal sensitization, acute systemic toxicity experiment, short term systemic toxicity experiment and skin stimulus experiment. MAIN OUTCOME MEASURES:: Porous structure and compressive strength of the composite; histological observations after implantation in muscle pouches; the rank score of acute systemic toxicity test and short term systemic toxicity experiment; the classification of dermal sensitization test; the score of skin stimulus experiment. RESULTS:: The composite material did not have acute toxicity, skin stimulation, and short term systemic toxicity. In addition, the composite material possessed a suitable porous structure (200-400 μ m) and mechanical strength. CONCLUSION:: The composite material has well biocompatibility.Wu TX, Yang WZ, Li YD, Zhang HJ, Chen LH, Zhou DL, Yin GF. Biocompatibility of biphasic calcium phosphate/poly L-lactic acid composite material. Zhongguo Zuzhi Gongcheng Yanjiu yu Linchuang Kangfu. 2009;13(21):4025-4028. [http://www.crter.cn http://en.zglckf.com]