부산대학교 도서관

Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) is an inflammatory disease in the central nervous system characterized by brainstem symptoms and distinctive radiological features, and responds favorably to steroid therapy. To date, only a few case reports pertaining to this condition have been published, and thus single-photon emission computed tomography findings of CLIPPERS have not been reported. Here, we document our experiences with an 86-year-old patient who we diagnosed with CLIPPERS according to her clinical presentation, radiological findings and favorable response to steroid therapy. N-isopropyl-p-[123I]iodoamphetamine single-photon emission computed tomography showed hypoperfusion in the pons, which was improved by steroid therapy. This case highlights the utility of N-isopropyl-p-[123I]iodoamphetamine single-photon emission computed tomography for assessing pontine dysfunction in CLIPPERS patients both before and after steroid therapy.