학술논문
Comparison of Two Methods of Estimating Reader Variability in QT Interval Measurements in Thorough QT/QTc Studies
Document Type
Academic Journal
Author
Source
Annals of Noninvasive Electrocardiology. Mar 01, 2014 19(2):182-189
Subject
Language
English
ISSN
1082-720X
Abstract
BACKGROUND:: Two methods of estimating reader variability (RV) in QT measurements between 12 readers were compared. METHODS:: Using data from 500 electrocardiograms (ECGs) analyzed twice by 12 readers, we bootstrapped 1000 datasets each for both methods. In grouped analysis design (GAD), the same 40 ECGs were read twice by all readers. In pairwise analysis design (PAD), 40 ECGs analyzed by each reader in a clinical trial were reanalyzed by the same reader (intra-RV) and also by another reader (inter-RV); thus, variability between each pair of readers was estimated using different ECGs. RESULTS:: Inter-RV (mean [95% CI]) between pairs of readers by GAD and PAD was 3.9 ms (2.1–5.5 ms) and 4.1 ms (2.6–5.4 ms), respectively, using ANOVA, 0 ms (–0.0 to 0.4 ms), and 0 ms (–0.7 to 0.6 ms), respectively, by actual difference between readers and 7.7 ms (6.2–9.8 ms) and 7.7 ms (6.6–9.1 ms), respectively, by absolute difference between readers. Intra-RV too was comparable. CONCLUSIONS:: RV estimates by the grouped- and pairwise analysis designs are comparable.