학술논문
Childhood allergic rhinitis, traffic-related air pollution, and variability in the GSTP1, TNF, TLR2, and TLR4 genes: Results from the TAG Study
Document Type
Academic Journal
Author
Fuertes, Elaine; Brauer, Michael; MacIntyre, Elaina; Bauer, Mario; Bellander, Tom; von Berg, Andrea; Berdel, Dietrich; Brunekreef, Bert; Chan-Yeung, Moira; Gehring, Ulrike; Herbarth, Olf; Hoffmann, Barbara; Kerkhof, Marjan; Klümper, Claudia; Koletzko, Sibylle; Kozyrskyj, Anita; Kull, Inger; Heinrich, Joachim; Melén, Erik; Pershagen, Göran; Postma, Dirkje; Tiesler, Carla M.T.; Carlsten, Chris
Source
The Journal of Allergy and Clinical Immunology. Aug 01, 2013 132(2):342-352e2
Subject
Language
English
ISSN
0091-6749
Abstract
BACKGROUND: OBJECTIVE: METHODS: Allergic rhinitis was defined with a doctor diagnosis or reported symptoms at age 7 or 8 years. Associations between nitrogen dioxide, particulate matter 2.5 (PM2.5) mass, PM2.5 absorbance, and ozone, estimated for each child at the year of birth, and single nucleotide polymorphisms within the GSTP1, TNF, TLR2, or TLR4 genes with allergic rhinitis and aeroallergen sensitization were examined with logistic regression. Models were stratified by genotype and interaction terms tested for gene-environment associations. RESULTS: CONCLUSION: The generally null effect of TRAP on allergic rhinitis and aeroallergen sensitization was not modified by the studied variants in the GSTP1, TNF, TLR2, or TLR4 genes. Children carrying a minor rs1800629 (TNF) or rs1927911 (TLR4) allele may be at a higher risk of allergic rhinitis.