학술논문
Roquin Paralogs 1 and 2 Redundantly Repress the Icos and Ox40 Costimulator mRNAs and Control Follicular Helper T Cell Differentiation
Document Type
Academic Journal
Author
Vogel, Katharina U.; Edelmann, Stephanie L.; Jeltsch, Katharina M.; Bertossi, Arianna; Heger, Klaus; Heinz, Gitta A.; Zöller, Jessica; Warth, Sebastian C.; Hoefig, Kai P.; Lohs, Claudia; Neff, Frauke; Kremmer, Elisabeth; Schick, Joel; Repsilber, Dirk; Geerlof, Arie; Blum, Helmut; Wurst, Wolfgang; Heikenwälder, Mathias; Schmidt-Supprian, Marc; Heissmeyer, Vigo
Source
Immunity. Apr 01, 2013 38(4):655-668
Subject
Language
English
ISSN
1074-7613
Abstract
SUMMARY: GRAPHICAL ABSTRACT: (Figure is included in full-text article.) HIGHLIGHTS: ★ Ox40 is a target of Roquin-1 and Roquin-2 ★ In Rc3h1-2-deficient cells the derepression of Ox40 activates NF-κB and Irf4 ★ Roquin-1 and Roquin-2 control inappropriate T cell activation and Tfh differentiation ★ Combined loss of Rc3h1 and Rc3h2 imposes Tfh differentiation on CD4 T cells